- Title
- Developing chemotherapeutics which disable the actin cytoskeleton of melanoma cells
- Creator
- Stehn, J. R.; Haass, N. K.; Hardeman, E.; Winlaw, D.; Weninger, W.; Gunning, P.; Desouza, M.; Sequeira, V. B.; Treutlein, H.; Zeng, J.; Nascimento, P. R. B. B.; Butler, T.; McCluskey, Adam; Palmer, S.
- Relation
- 2011 International Melanoma Congress. Pigment Cell & Melanoma Research (Tampa, FL 9-13 November, 2011) p. 1058
- Publisher Link
- http://dx.doi.org/10.1111/j.1755-148X.2011.00909.x
- Publisher
- Wiley-Blackwell Publishing
- Resource Type
- conference paper
- Date
- 2011
- Description
- To treat aggressive cancers such as melanoma it is imperative that new chemotherapeutic targets and agents be developed. The actin cytoskeleton, due to its role in biological processes fundamental to cellular transformation, has always been a sought after chemotherapeutic target. However, despite many years of research, attempts to develop actin targeting drugs for chemotherapy remains unsuccessful due to their lack of specificity which ultimately causes unacceptable cardiac and respiratory toxicity.
- Subject
- aggressive; melanoma; cardiac; respiratory toxicity
- Identifier
- http://hdl.handle.net/1959.13/1036280
- Identifier
- uon:13243
- Identifier
- ISSN:1755-148X
- Language
- eng
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